Intensity of liver parenchym fibrosis in patients with alcoholic and non-alcoholic steatohepatitis depending on the presence of dysmetabolic iron overload syndrome

Objective — to establish the features of iron homeostasis in patients with steatohepatitis alcoholic and nonalcoholic etiology depending on presence dysmetobolic overload syndrome, identify probable link between ferrokinetics markers biochemical syndromes steatohepatitis, intensity endotoxicosis fibrosing reactions.
 Materials methods. The study was based clinical follow‑up 125 individuals, including 60 65 25 practically healthy individuals appropriate age gender. Depending indicators homeostasis, examined were divided into 4 groups: dysmetabolic syndrome 40 patients, without syndrome; 18 non‑alcoholic 42 syndrome.
 Results. In activation collagen anabolism processes observed through growth protein‑bound oxyproline blood 2.5 times (p < 0.05), absence 2.0 as well a significant increase catabolism by increasing content free blood, respectively 1.5 1.3 which occurred due collagenolytic activity plasma (respectively 1.6 1.4 times; p 0.05) intergroup difference all cases. There hexosamines blood: its sialic acids, accelerated degradation fucoglycoprotein components extracellular matrix. synthesis an established slight breakdown 1.2 0.05). also fucoglycoproteins.
 Conclusions. regularities liver fibrosis progression are inextricably linked anabolism, catabolism, plasma. An important consequence cytolysis inflammation is blood. there synthesis, characteristic hexosamines,